Database
Medications and dry mouth, A to Z
Every entry checked against FDA labeling, published literature, and post-marketing reporting — and each one tells you which of those it rests on.
Includes prescriptions, over-the-counter medications, supplements, and the oral-care products people use daily — mouthwash, toothpaste, and dental materials, which are almost never included anywhere else and are a genuine cause of burning and taste change.
Entries marked not a known cause are here on purpose. Confirming that a medication is not the problem is as useful as finding one that is.
#
- "Detox" / "Water Pill" blends — Commonly causes dryness
- 5-HTP — Sometimes
A
- Abatacept (Orencia) — Rarely
- Abemaciclib (Verzenio) — Commonly causes dryness
- Abrocitinib (Cibinqo) — Rarely
- Acalabrutinib (Calquence) — Sometimes
- Acamprosate (acamprosate calcium) — Sometimes
- Acarbose (Precose) — Rarely
- Acetaminophen — Sometimes
- Acetazolamide (Diamox) — Sometimes
- Acitretin (ACITRETIN, Acitretin) — Sometimes
- Aclidinium (Tudorza Pressair) — Commonly causes dryness
- Adalimumab (Humira) — Sometimes
- Adapalene (Differin) — Rarely
- Aducanumab (Aduhelm) — Sometimes
- Afamelanotide (Scenesse) — Rarely
- Albendazole (Albenza) — Rarely
- Albiglutide (Tanzeum) — Sometimes
- Albuterol/Ipratropium (Combivent) — Commonly causes dryness
- Alclometasone (Aclovate) — Rarely
- Alcohol (in oral rinses) (Many antiseptic mouthwashes) — Irritates directly
- Alectinib (Alecensa) — Rarely
- Alendronate (Fosamax) — Rarely
- Alfuzosin (Uroxatral) — Rarely
- Alitretinoin (Panretin) — Commonly causes dryness
- Allopurinol (Zyloprim) — Rarely
- Almotriptan — Sometimes
- Alpelisib (Piqray) — Rarely
- Alpha-Lipoic Acid (ALA) — Treats dry mouth
- Alprazolam (Xanax) — Can go either way
- Alprostadil — Sometimes
- Amantadine (Symmetrel) — Sometimes
- Ambrisentan (Letairis) — Rarely
- Amikacin — Sometimes
- Amiodarone (Cordarone) — Rarely
- Amitiza (Lubiprostone) — Rarely
- Amitriptyline (Elavil) — Can go either way
- Amivantamab (Rybrevant) — Sometimes
- Amlodipine (Norvasc) — Rarely
- Amphetamine/Dextroamphetamine (Adderall) — Commonly causes dryness
- Anagrelide — Sometimes
- Anastrozole (Arimidex) — Rarely
- Andexanet alfa (Andexxa) — Rarely
- Anifrolumab (Saphnelo) — Rarely
- Apalutamide (Erleada) — Rarely
- Apixaban (Eliquis) — Not a known cause
- Apomorphine (Apokyn) — Sometimes
- Apple Cider Vinegar — Irritates directly
- Apraclonidine (Apraclonidine) — Sometimes
- Apremilast (Otezla) — Rarely
- Aprepitant (Emend) — Sometimes
- Arformoterol (Brovana) — Sometimes
- Aripiprazole (Abilify) — Can go either way
- Armodafinil (Nuvigil) — Sometimes
- Arsenic Trioxide (Trisenox) — Commonly causes dryness
- Articaine with epinephrine (Septocaine, Orabloc) — Irritates directly
- Asciminib (Scemblix) — Sometimes
- Asenapine (Saphris) — Can go either way
- Aspirin — Sometimes
- Atenolol (Tenormin) — Can go either way
- Atomoxetine (Strattera) — Commonly causes dryness
- Atorvastatin (Lipitor) — Not a known cause
- Atropine (Atropen) — Can go either way
- Avacopan (Tavneos) — Rarely
- Avanafil (Stendra) — Rarely
- Avapritinib (Ayvakit) — Can go either way
- Avatrombopag (Doptelet) — Rarely
- Avelumab — Sometimes
- Axicabtagene ciloleucel (Yescarta) — Commonly causes dryness
- Azacitidine (Vidaza) — Sometimes
- Azathioprine (Imuran) — Sometimes
- Azelastine (ophthalmic) (Optivar) — Sometimes
- Azithromycin — Sometimes
B
- Baclofen (Lioresal) — Can go either way
- Balsalazide (Balsalazide Disodium, balsalazide disodi) — Sometimes
- Bamipine — Sometimes
- Baricitinib (Olumiant) — Sometimes
- Bazedoxifene — Sometimes
- Beclomethasone (Qvar) — Sometimes
- Belantamab Mafodotin (Blenrep) — Sometimes
- Belimumab (Benlysta) — Sometimes
- Belladonna Alkaloids (Donnatal) — Commonly causes dryness
- Belzutifan (Welireg) — Rarely
- Bempedoic Acid — Sometimes
- Benazepril — Sometimes
- Bendamustine (Treanda) — Commonly causes dryness
- Benzocaine (Orajel and similar) — Irritates directly
- Benzonatate (Tessalon Perles) — Sometimes
- Benztropine (Cogentin) — Can go either way
- Bepotastine — Sometimes
- Beremagene geperpavec (Vyjuvek) — Rarely
- Berotralstat (Orladeyo) — Rarely
- Betamethasone (Diprolene) — Rarely
- Betaxolol (Kerlone) — Rarely
- Bexarotene (Targretin) — Commonly causes dryness
- Bimekizumab (Bimzelx) — Sometimes
- Binimetinib (Mektovi) — Rarely
- Biperiden (Akineton) — Can go either way
- Bisoprolol (Bisoprolol Fumarate, Bisoprolol fumarate) — Sometimes
- Bitter Orange (Synephrine) — Commonly causes dryness
- Blinatumomab (Blincyto) — Rarely
- Bortezomib — Sometimes
- Bosentan (Tracleer) — Rarely
- Bosutinib (Bosulif) — Commonly causes dryness
- Botulinum Toxin Type A — Sometimes
- Brentuximab vedotin (Adcetris) — Sometimes
- Brexpiprazole (Rexulti) — Commonly causes dryness
- Brexucabtagene Autoleucel — Sometimes
- Brigatinib (Alunbrig) — Rarely
- Brimonidine (ophthalmic) (Alphagan) — Commonly causes dryness
- Bromazepam (Lectopam) — Can go either way
- Bromocriptine (Parlodel) — Sometimes
- Brompheniramine (Dimetapp) — Can go either way
- Budesonide/Formoterol (Symbicort) — Sometimes
- Budipine — Sometimes
- Bupivacaine (Marcaine) — Irritates directly
- Buprenorphine (Suboxone, Subutex, Belbuca) — Commonly causes dryness
- Bupropion (Wellbutrin) — Commonly causes dryness
- Buspirone (Buspar) — Can go either way
- Butylscopolamine — Sometimes
C
- Cabergoline (Dostinex) — Sometimes
- Cabozantinib (Cabometyx) — Commonly causes dryness
- Caffeine — Sometimes
- Calcium carbonate (Tums, Caltrate) — Not a known cause
- Canagliflozin (Invokana) — Rarely
- Canakinumab (Ilaris) — Sometimes
- Candesartan (Atacand) — Rarely
- Cannabis (THC, any route) — Commonly causes dryness
- Cannabis / THC (any route) — Commonly causes dryness
- Capecitabine (Xeloda) — Commonly causes dryness
- Capivasertib (Truqap) — Rarely
- Caplacizumab (Cablivi) — Rarely
- Capmatinib (Tabrecta) — Rarely
- Carbamazepine (Tegretol) — Can go either way
- Carbidopa (Lodosyn) — Can go either way
- Cariprazine — Sometimes
- Carvedilol (CARVEDILOL, Carvedilol, Coreg) — Sometimes
- Caspofungin (Cancidas) — Rarely
- CBD — Sometimes
- Cefdinir (Omnicef) — Rarely
- Ceftibuten — Sometimes
- Cefuroxime (Ceftin) — Rarely
- Celecoxib (CELECOXIB, Celecoxib, celecoxib) — Sometimes
- Cemiplimab (Libtayo) — Sometimes
- Cenobamate (Xcopri) — Sometimes
- Cerliponase alfa (Brineura) — Rarely
- Cetirizine (Zyrtec) — Can go either way
- Cetylpyridinium chloride (Crest Pro-Health, some Colgate rinses) — Irritates directly
- Cevimeline (Evoxac) — Treats dry mouth
- Chlorhexidine — Sometimes
- Chlorhexidine gluconate (Peridex, PerioGard, generic oral rinse) — Irritates directly
- Chlorothiazide (Diuril) — Sometimes
- Chlorpheniramine (Chlor-Trimeton) — Commonly causes dryness
- Chlorpromazine (Thorazine) — Can go either way
- Chlorthalidone (Thalitone) — Sometimes
- Ciltacabtagene autoleucel (Carvykti) — Sometimes
- Cinnamon supplements / cinnamon oil — Irritates directly
- Cinnarizine — Sometimes
- Cisplatin (Platinol) — Commonly causes dryness
- Citalopram (Celexa) — Sometimes
- Cladribine (Mavenclad) — Sometimes
- Clascoterone (Winlevi) — Rarely
- Clemastine (Tavist) — Commonly causes dryness
- Clidinium (Librax) — Commonly causes dryness
- Clindamycin (topical) (Cleocin T) — Rarely
- Clobazam (Onfi) — Can go either way
- Clobetasol (Temovate) — Rarely
- Clomipramine (Anafranil) — Commonly causes dryness
- Clonazepam (Klonopin) — Can go either way
- Clonidine (Catapres) — Can go either way
- Clonidine ER (Kapvay) — Commonly causes dryness
- Clopidogrel (Plavix) — Not a known cause
- Clove oil / Eugenol — Irritates directly
- Clozapine (Clozaril) — Can go either way
- Codeine (Various) — Can go either way
- Colchicine (Colcrys) — Not a known cause
- Colesevelam (Welchol) — Rarely
- Creatine — Sometimes
- Crisaborole (Eucrisa) — Rarely
- Crizanlizumab (Adakveo) — Rarely
- Crizotinib (Xalkori) — Rarely
- Cyclobenzaprine (Flexeril) — Commonly causes dryness
- Cyclophosphamide (Cytoxan) — Commonly causes dryness
- Cyclosporine (Neoral) — Sometimes
- Cyproheptadine (Periactin) — Commonly causes dryness
D
- Dabrafenib (Tafinlar) — Rarely
- Dacarbazine (DTIC-Dome) — Sometimes
- Dacomitinib — Sometimes
- Danazol (Danocrine) — Rarely
- Dandelion Root — Sometimes
- Dantrolene (Dantrium) — Sometimes
- Dapagliflozin (Farxiga) — Rarely
- Daprodustat (Jesduvroq) — Rarely
- Daratumumab (Darzalex) — Sometimes
- Daridorexant (Quviviq) — Rarely
- Darifenacin (Enablex) — Commonly causes dryness
- Darolutamide (Nubeqa) — Rarely
- Darunavir (Prezista) — Rarely
- Deflazacort (Emflaza) — Rarely
- Delafloxacin (Baxdela) — Rarely
- Delavirdine (Rescriptor) — Rarely
- Dengue Virus Live Antigen, Cyd Serotype 1 — Sometimes
- Dengue Virus Live Antigen, Cyd Serotype 2 — Sometimes
- Dengue Virus Live Antigen, Cyd Serotype 3 — Sometimes
- Dengue Virus Live Antigen, Cyd Serotype 4 — Sometimes
- Denosumab (Prolia) — Rarely
- Desipramine (Norpramin) — Commonly causes dryness
- Desloratadine (nasal) (Clarinex) — Rarely
- Desmopressin — Sometimes
- Desoximetasone (Topicort) — Rarely
- Desvenlafaxine (Pristiq) — Commonly causes dryness
- Deucravacitinib (Sotyktu) — Rarely
- Deutetrabenazine — Sometimes
- Dexchlorpheniramine — Sometimes
- Dexlansoprazole (Dexilant) — Rarely
- Dexmedetomidine (Dexmedetomidine, Dexmedetomidine in Dext) — Sometimes
- Dexmethylphenidate (Focalin) — Commonly causes dryness
- Dexrazoxane — Sometimes
- Dextroamphetamine (Dexedrine) — Commonly causes dryness
- Dextromethorphan — Sometimes
- DHEA — Rarely
- Diazepam (Valium) — Can go either way
- Diclofenac (DICLOFENAC SODIUM, Diclofenac Sodium, Di) — Sometimes
- Dicyclomine (Bentyl) — Commonly causes dryness
- Diethylstilbestrol (Stilphostrol) — Rarely
- Dihydrocodeine — Sometimes
- Diltiazem (Cardizem) — Rarely
- Dimenhydrinate (Dramamine) — Commonly causes dryness
- Dinoprostone — Sometimes
- Dinutuximab (Unituxin) — Sometimes
- Diphenhydramine (Benadryl) — Commonly causes dryness
- Diphenoxylate/Atropine (Lomotil) — Commonly causes dryness
- Disulfiram (Antabuse) — Rarely
- Docetaxel — Sometimes
- Dolasetron (Anzemet) — Sometimes
- Domperidone — Sometimes
- Donepezil (Aricept) — Can go either way
- Dostarlimab (Jemperli) — Sometimes
- Dotatate — Sometimes
- Dothiepin — Sometimes
- Doxepin (Silenor) — Can go either way
- Doxycycline (Vibramycin) — Rarely
- Doxylamine (Unisom) — Commonly causes dryness
- Dronabinol (Marinol) — Commonly causes dryness
- Dronedarone (Multaq) — Rarely
- Drospirenone — Sometimes
- Droxidopa (Northera) — Sometimes
- Dulaglutide (Trulicity) — Sometimes
- Duloxetine (Cymbalta) — Commonly causes dryness
- Dupilumab (Dupixent) — Sometimes
E
- Edrophonium (Enlon) — Rarely
- Efavirenz (Sustiva) — Rarely
- Efgartigimod (Vyvgart) — Rarely
- Efgartigimod alfa (Vyvgart) — Rarely
- Elacestrant (Orserdu) — Rarely
- Elagolix (Orilissa) — Rarely
- Eletriptan (Eletriptan HBR) — Sometimes
- Elexacaftor/Tezacaftor/Ivacaftor (Trikafta) — Rarely
- Eliglustat (Cerdelga) — Rarely
- Elivaldogene autotemcel (Skysona) — Rarely
- Elotuzumab (Empliciti) — Rarely
- Elranatamab (Elrexfio) — Rarely
- Eltrombopag (Promacta) — Rarely
- Emapalumab (Gamifant) — Sometimes
- Empagliflozin (Jardiance) — Rarely
- Emtricitabine (Emtriva) — Rarely
- Enalapril (Vasotec) — Not a known cause
- Encorafenib (Braftovi) — Rarely
- Enfortumab vedotin (Padcev) — Commonly causes dryness
- Entacapone (Comtan) — Can go either way
- Entrectinib (Rozlytrek) — Rarely
- Enzalutamide (Xtandi) — Rarely
- Epcoritamab (Epkinly) — Rarely
- Ephedra / Ma Huang — Commonly causes dryness
- Ephedrine — Sometimes
- Eplerenone (Inspra) — Rarely
- Eplontersen (Wainua) — Rarely
- Epoprostenol — Sometimes
- Eravacycline (Xerava) — Rarely
- Ergotamine (Cafergot) — Rarely
- Eribulin (Halaven) — Commonly causes dryness
- Erlotinib (Tarceva) — Rarely
- Erythromycin (Ery-Tab) — Can go either way
- Escitalopram (Lexapro) — Sometimes
- Esketamine — Sometimes
- Esmolol (BREVIBLOC, Esmolol Hydrochloride) — Sometimes
- Esomeprazole (Esomeprazole sodium) — Sometimes
- Estetrol — Sometimes
- Estrogens, Conjugated (Usp) — Sometimes
- Eszopiclone (Lunesta) — Sometimes
- Etanercept (Enbrel) — Sometimes
- Ethambutol (Myambutol) — Rarely
- Ethinyl estradiol/norgestimate (Ortho Tri-Cyclen) — Rarely
- Etoposide — Sometimes
- Etranacogene dezaparvovec (Hemgenix) — Rarely
- Etravirine (Intelence) — Rarely
- Everolimus (Afinitor) — Commonly causes dryness
- Exenatide (Byetta, Bydureon) — Sometimes
- Ezetimibe — Sometimes
- Ezogabine — Sometimes
F
- Factor Viii — Sometimes
- Faricimab (Vabysmo) — Sometimes
- Febuxostat (Uloric) — Rarely
- Fedratinib (Inrebic) — Rarely
- Felbamate (Felbatol) — Sometimes
- Fentanyl (Duragesic) — Can go either way
- Ferumoxytol — Sometimes
- Fesoterodine (Toviaz) — Commonly causes dryness
- Fexinidazole (Fexinidazole) — Can go either way
- Fexofenadine (Allegra) — Can go either way
- Fezolinetant (Veozah) — Rarely
- Fidaxomicin (Dificid) — Rarely
- Filgotinib (Jyseleca) — Rarely
- Filgrastim (Neupogen) — Rarely
- Finasteride (Propecia) — Rarely
- Fingolimod (Gilenya) — Sometimes
- Fish oil / Omega-3 — Not a known cause
- Flecainide (Tambocor) — Rarely
- Flibanserin — Sometimes
- Fluconazole (Diflucan) — Can go either way
- Flucytosine (Ancobon) — Rarely
- Fludarabine (Fludara) — Commonly causes dryness
- Fluocinonide (Lidex) — Rarely
- Fluorouracil (Adrucil) — Commonly causes dryness
- Fluoxetine (Prozac) — Sometimes
- Flupenthixol — Sometimes
- Fluphenazine (Prolixin) — Can go either way
- Flutamide (Eulexin) — Rarely
- Fluticasone/Salmeterol (Advair) — Sometimes
- Fluvoxamine (Luvox) — Sometimes
- Folic acid (Folate) — Not a known cause
- Fosdenopterin (Nulibry) — Rarely
- Fostamatinib (Tavalisse) — Rarely
- Frovatriptan (frovatriptan succinate) — Sometimes
- Fruquintinib (Fruzaqla) — Sometimes
- Fulvestrant (Faslodex) — Rarely
- Furosemide (Lasix) — Commonly causes dryness
- Futibatinib (Lytgobi) — Rarely
G
- Gabapentin (Neurontin) — Sometimes
- Galantamine (Razadyne) — Can go either way
- Galcanezumab (Emgality) — Rarely
- Ganciclovir (Cytovene) — Rarely
- Gavreto (Pralsetinib) — Sometimes
- Gefitinib (Iressa) — Commonly causes dryness
- Gemcitabine (Gemzar) — Commonly causes dryness
- Gemfibrozil (Lopid) — Rarely
- Gilteritinib (Xospata) — Rarely
- Givosiran (Givlaari) — Rarely
- Glasdegib (Daurismo) — Rarely
- Glecaprevir/Pibrentasvir (Mavyret) — Rarely
- Glipizide (Glucotrol) — Rarely
- Glofitamab (Columvi) — Rarely
- Glyburide (Diabeta) — Rarely
- Glycopyrrolate (Robinul) — Commonly causes dryness
- Glycopyrrolate/Formoterol (Bevespi) — Commonly causes dryness
- Glycopyrronium — Sometimes
- Golimumab (Simponi) — Sometimes
- Goserelin — Sometimes
- Granisetron — Sometimes
- Green Tea Extract / EGCG — Sometimes
- Guaifenesin — Sometimes
- Guanfacine (Intuniv) — Commonly causes dryness
- Guanfacine ER (Intuniv) — Commonly causes dryness
- Guarana — Commonly causes dryness
- Guselkumab (Tremfya) — Sometimes
H
- Haloperidol (Haldol) — Can go either way
- Halothane (Fluothane) — Sometimes
- Hexetidine — Sometimes
- Horsetail — Sometimes
- Hydralazine (Apresoline) — Rarely
- Hydrochlorothiazide (Microzide) — Can go either way
- Hydrochlorothiazide/Triamterene (Dyazide) — Sometimes
- Hydrocodone (Vicodin) — Commonly causes dryness
- Hydroxychloroquine (Plaquenil) — Rarely
- Hydroxyurea (Hydrea) — Commonly causes dryness
- Hydroxyzine (Vistaril) — Commonly causes dryness
- Hyoscyamine (Levsin) — Commonly causes dryness
I
- Ibrutinib (Imbruvica) — Sometimes
- Ibuprofen (Ibuprofen) — Sometimes
- Ibutilide (Corvert) — Rarely
- Idecabtagene vicleucel (Abecma) — Sometimes
- Idelalisib (Zydelig) — Rarely
- Ifosfamide (Ifex) — Can go either way
- Iloperidone (Fanapt) — Commonly causes dryness
- Imatinib (Gleevec) — Commonly causes dryness
- Imipramine (Tofranil) — Can go either way
- Imiquimod — Sometimes
- Immunoglobulin (Gammagard) — Rarely
- Inclisiran (Leqvio) — Rarely
- Indacaterol (Arcapta Neohaler) — Sometimes
- Indapamide (Lozol) — Sometimes
- Indinavir (Crixivan) — Rarely
- Indomethacin — Sometimes
- Indoramin — Sometimes
- Inebilizumab (Uplizna) — Sometimes
- Infigratinib (Truseltiq) — Rarely
- Infliximab (Remicade) — Sometimes
- Inotuzumab Ozogamicin (Besponsa) — Sometimes
- Insulin (any) — Not a known cause
- Ipratropium (nasal) (Atrovent Nasal) — Commonly causes dryness
- Iptacopan (Fabhalta) — Rarely
- Irbesartan — Sometimes
- Irinotecan (Camptosar) — Can go either way
- Iron supplements — Rarely
- Isatuximab (Sarclisa) — Sometimes
- Isavuconazonium (Cresemba) — Rarely
- Isocarboxazid (Marplan) — Sometimes
- Isoniazid — Sometimes
- Isosorbide — Sometimes
- Isotretinoin (Accutane) — Commonly causes dryness
- Isradipine (DynaCirc) — Rarely
- Itraconazole (Sporanox) — Rarely
- Ivabradine (Corlanor) — Rarely
- Ivosidenib (Tibsovo) — Rarely
- Ixazomib (Ninlaro) — Sometimes
- Ixekizumab (Taltz) — Sometimes
J
- Juniper Berry — Sometimes
K
- Kava — Sometimes
- Ketamine (Ketalar) — Can go either way
- Ketoconazole (Nizoral) — Rarely
L
- Labetalol (Trandate) — Rarely
- Lacosamide (Vimpat) — Sometimes
- Lamivudine — Sometimes
- Lamotrigine (Lamictal) — Can go either way
- Lanadelumab (Takhzyro) — Rarely
- Lanreotide (Somatuline) — Rarely
- Lansoprazole/Amoxicillin/Clarithromycin (PrevPac) — Rarely
- Lapatinib (Tykerb) — Can go either way
- Larotrectinib (Vitrakvi) — Rarely
- Lasmiditan (Reyvow) — Rarely
- Lecanemab (Leqembi) — Rarely
- Ledipasvir/Sofosbuvir (Harvoni) — Rarely
- Lenacapavir (Sunlenca) — Rarely
- Lenalidomide (Lenalidomide) — Sometimes
- Leniolisib (Joenja) — Rarely
- Lenvatinib (Lenvima) — Commonly causes dryness
- Leqembi (Lecanemab) — Sometimes
- Letermovir (Prevymis) — Rarely
- Letrozole (Femara) — Rarely
- Leuprolide (Lupron) — Rarely
- Levetiracetam (Keppra) — Sometimes
- Levocetirizine (Xyzal) — Sometimes
- Levodopa/Carbidopa (Sinemet) — Sometimes
- Levothyroxine (Synthroid, Levoxyl) — Not a known cause
- Licorice Root (glycyrrhizin) — Sometimes
- Lidocaine — Sometimes
- Linagliptin (Tradjenta) — Rarely
- Linezolid (Zyvox) — Rarely
- Liraglutide (Victoza) — Can go either way
- Lisdexamfetamine (Vyvanse) — Commonly causes dryness
- Lisinopril (Zestril, Prinivil) — Not a known cause
- Liso-cel (Lisocabtagene maraleucel) (Breyanzi) — Sometimes
- Lisocabtagene maraleucel (Breyanzi) — Sometimes
- Lithium (Lithobid) — Can go either way
- Lojuxta (Lomitapide) — Rarely
- Lomitapide (Juxtapid) — Rarely
- Lomustine (CeeNU) — Sometimes
- Loperamide (Imodium) — Sometimes
- Loratadine (Claritin) — Rarely
- Loratadine/Phenylephrine (Claritin-D) — Sometimes
- Loratadine/Pseudoephedrine (Claritin-D) — Sometimes
- Lorazepam (Ativan) — Can go either way
- Lorlatinib (Lorbrena) — Rarely
- Losartan (Cozaar) — Not a known cause
- Lovastatin (Mevacor) — Rarely
- Loxapine — Sometimes
- Lumasiran (Oxlumo) — Rarely
- Lumateperone — Sometimes
- Lurasidone (Latuda) — Can go either way
- Lurbinectedin (Zepzelca) — Rarely
- Luspatercept (Reblozyl) — Rarely
M
- Macitentan (Opsumit) — Rarely
- Magnesium (Mag oxide, mag glycinate) — Not a known cause
- Maralixibat (Livmarli) — Rarely
- Maraviroc (Selzentry) — Rarely
- Mavacamten (Camzyos) — Rarely
- Mechlorethamine (Mustargen) — Commonly causes dryness
- Meclizine (Antivert) — Sometimes
- Medroxyprogesterone (Provera) — Rarely
- Mefenamate — Sometimes
- Megestrol (Megace) — Rarely
- Melatonin — Sometimes
- Meloxicam (MELOXICAM, Meloxicam, meloxicam) — Sometimes
- Melphalan (Alkeran) — Commonly causes dryness
- Memantine (Namenda) — Rarely
- Menthol / mint flavoring (Most toothpastes and rinses) — Irritates directly
- Meperidine (Meperidine Hydrochloride) — Sometimes
- Mepolizumab (Nucala) — Sometimes
- Mercaptopurine (Purinethol) — Sometimes
- Mesalamine (Mesalamine) — Sometimes
- Mesna (MESNEX) — Sometimes
- Metaxalone (Skelaxin) — Sometimes
- Metformin (Glucophage) — Rarely
- Methadone (Dolophine, Methadose) — Commonly causes dryness
- Methantheline (Banthine) — Commonly causes dryness
- Methimazole (Tapazole) — Rarely
- Methotrexate (Trexall) — Can go either way
- Methotrimeprazine — Sometimes
- Methoxsalen — Sometimes
- Methscopolamine (Pamine) — Commonly causes dryness
- Methsuximide (Celontin) — Sometimes
- Methyl salicylate (Listerine, some toothpastes) — Irritates directly
- Methylphenidate (Ritalin) — Can go either way
- Metoclopramide (Reglan) — Can go either way
- Metoprolol (Lopressor) — Rarely
- Metronidazole (Flagyl) — Rarely
- Midodrine (ProAmatine) — Sometimes
- Midostaurin (Rydapt) — Rarely
- Mifepristone — Sometimes
- Migalastat — Sometimes
- Milnacipran (Savella) — Commonly causes dryness
- Minocycline (Minocin) — Rarely
- Mirabegron (Myrbetriq) — Rarely
- Mirikizumab (Omvoh) — Sometimes
- Mirtazapine (Remeron) — Can go either way
- Mirvetuximab soravtansine (Elahere) — Sometimes
- Mitomycin (Mutamycin) — Commonly causes dryness
- Mitotane (Lysodren) — Sometimes
- Mitoxantrone (Novantrone) — Commonly causes dryness
- Mobocertinib (Exkivity) — Sometimes
- Modafinil (Provigil) — Sometimes
- Mogamulizumab (Poteligeo) — Rarely
- Mometasone/Formoterol (Dulera) — Sometimes
- Monjuvi (Tafasitamab) — Sometimes
- Morphine (MS Contin) — Commonly causes dryness
- Mosunetuzumab (Lunsumio) — Rarely
- Moxifloxacin (Moxifloxacin) — Sometimes
- Moxonidine — Sometimes
- Mupirocin (Bactroban) — Rarely
- Mycophenolate (CellCept) — Sometimes
- Mycophenolate mofetil (CellCept) — Sometimes
N
- Nabilone (Cesamet) — Commonly causes dryness
- Nadolol (NADOLOL, Nadolol) — Sometimes
- Nalidixic Acid (NegGram) — Rarely
- Nalmefene — Sometimes
- Naloxone — Sometimes
- Naltrexone (ReVia, Vivitrol, in Contrave) — Sometimes
- Naproxen (Naproxen) — Sometimes
- Naxitamab (Danyelza) — Sometimes
- Nefazodone (Nefazodone Hydrochloride) — Sometimes
- Nelarabine (Arranon) — Sometimes
- Nelfinavir (Viracept) — Rarely
- Neostigmine — Sometimes
- Neratinib (Nerlynx) — Sometimes
- Netarsudil (Rhopressa) — Rarely
- Netupitant — Sometimes
- Nevirapine (Viramune) — Rarely
- Niacin (high dose) — Rarely
- Nicardipine (Nicardipine Hydrochloride) — Sometimes
- Nicotine (all forms) (Gum, lozenge, patch, pouches, vape) — Commonly causes dryness
- Nifedipine (Procardia) — Rarely
- Nilotinib (Tasigna) — Commonly causes dryness
- Nilutamide (Nilandron) — Rarely
- Nintedanib (Ofev) — Sometimes
- Niraparib (Zejula) — Commonly causes dryness
- Nirogacestat (Ogsiveo) — Rarely
- Nirsevimab (Beyfortus) — Sometimes
- Nitric Oxide — Sometimes
- Nitrofurantoin (Macrobid) — Rarely
- Nitrogen — Sometimes
- Nivolumab (Opdivo) — Commonly causes dryness
- Nizatidine — Sometimes
- Nortriptyline (Pamelor) — Commonly causes dryness
O
- Obeticholic acid (Ocaliva) — Rarely
- Obinutuzumab (Gazyva) — Sometimes
- Odevixibat (Bylvay) — Rarely
- Ofatumumab (Arzerra) — Sometimes
- Oil of Oregano — Irritates directly
- Olanzapine (Zyprexa) — Can go either way
- Olaparib (Lynparza) — Commonly causes dryness
- Olipudase alfa (Xenpozyme) — Rarely
- Olmesartan (Benicar) — Rarely
- Olopatadine (Patanol) — Sometimes
- Olsalazine — Sometimes
- Omacetaxine mepesuccinate (Synribo) — Rarely
- Omadacycline (Nuzyra) — Rarely
- Omaveloxolone (Skyclarys) — Rarely
- Omidenepag (Eybelis) — Rarely
- Omidenepag isopropyl (Omlonti) — Rarely
- Onasemnogene abeparvovec (Zolgensma) — Rarely
- Ondansetron (Zofran) — Can go either way
- Opdualag (Nivolumab/Relatlimab) — Sometimes
- Opicapone (Ongentys) — Sometimes
- Orlistat (Alli / Xenical) — Rarely
- Orphenadrine (ORPHENADRINE CITRATE, Orphenadrine Citra) — Sometimes
- Oseltamivir (Tamiflu) — Rarely
- Osilodrostat (Isturisa) — Rarely
- Osimertinib (Tagrisso) — Sometimes
- Oxaliplatin (Eloxatin) — Commonly causes dryness
- Oxcarbazepine (Trileptal) — Can go either way
- Oxybutynin (Ditropan) — Commonly causes dryness
- Oxycodone (OxyContin) — Commonly causes dryness
- Oxymetazoline (Afrin) — Sometimes
- Ozanimod (Zeposia) — Sometimes
P
- Paclitaxel — Sometimes
- Palbociclib (Ibrance) — Commonly causes dryness
- Paliperidone (Invega) — Can go either way
- Palonosetron (posfrea) — Sometimes
- Panitumumab (Vectibix) — Commonly causes dryness
- Pantoprazole (Protonix) — Rarely
- Paricalcitol (Zemplar) — Rarely
- Paroxetine (Paxil) — Commonly causes dryness
- Paroxetine/Clonazepam (Generic combo) — Sometimes
- Parsley Extract — Rarely
- Pasireotide (Signifor) — Rarely
- Paxlovid (Nirmatrelvir/Ritonavir) — Rarely
- Pazopanib (Votrient) — Commonly causes dryness
- Peficitinib (Smyraf) — Sometimes
- Pegaspargase (Oncaspar) — Sometimes
- Pegcetacoplan (Empaveli) — Rarely
- Peginterferon alfa-2a (Pegasys) — Sometimes
- Pegunigalsidase alfa (Elfabrio) — Rarely
- Pembrolizumab — Sometimes
- Pemigatinib (Pemazyre) — Rarely
- Penicillamine (Cuprimine) — Rarely
- Pentostatin (Nipent) — Rarely
- Pentoxifylline (Trental) — Rarely
- Peppermint / Mint oil products — Irritates directly
- Perampanel (Fycompa) — Sometimes
- Perindopril (Aceon) — Rarely
- Perjeta (Pertuzumab) — Sometimes
- Perphenazine (Trilafon) — Commonly causes dryness
- Pexidartinib (Turalio) — Rarely
- Phenelzine (Nardil) — Sometimes
- Phenobarbital (Luminal) — Can go either way
- Phenylephrine (Sudafed PE) — Sometimes
- Phenytoin (Dilantin) — Sometimes
- Pilocarpine (Salagen) — Treats dry mouth
- Pimozide (Orap) — Commonly causes dryness
- Pioglitazone (Actos) — Rarely
- Pirfenidone (Esbriet) — Rarely
- Piroxicam (Piroxicam) — Sometimes
- Pirtobrutinib (Jaypirca) — Sometimes
- Pitavastatin (Livalo) — Rarely
- Pitolisant — Sometimes
- Plerixafor (Mozobil) — Rarely
- Polatuzumab Vedotin (Polivy) — Rarely
- Pomalidomide (Pomalyst) — Rarely
- Ponatinib (Iclusig) — Sometimes
- Ponesimod (Ponvory) — Sometimes
- Pralatrexate (Folotyn) — Sometimes
- Pralsetinib (Gavreto) — Rarely
- Pramipexole (Mirapex) — Can go either way
- Pravastatin (Pravachol) — Rarely
- Prazepam (Centrax) — Sometimes
- Pre-workout blends — Commonly causes dryness
- Prednisolone (Orapred) — Rarely
- Prednisone (Deltasone) — Rarely
- Pregabalin (Lyrica) — Can go either way
- Primidone (Mysoline) — Sometimes
- Probiotics — Not a known cause
- Procarbazine (Matulane) — Commonly causes dryness
- Prochlorperazine (Compazine) — Commonly causes dryness
- Procyclidine — Sometimes
- Promazine (Sparine) — Commonly causes dryness
- Promethazine (Phenergan) — Commonly causes dryness
- Propafenone (Rythmol) — Can go either way
- Propantheline (Pro-Banthine) — Commonly causes dryness
- Propiverine (Detrunorm) — Commonly causes dryness
- Propranolol (Inderal) — Can go either way
- Protriptyline (Vivactil) — Commonly causes dryness
- PT010 (Breztri Aerosphere) — Sometimes
- Pyridostigmine (Mestinon) — Can go either way
- Pyrilamine — Sometimes
Q
- Quetiapine (Seroquel) — Can go either way
- Quinapril (Accupril) — Rarely
- Quinidine — Sometimes
R
- Rabeprazole (Aciphex, RABEPRAZOLE SODIUM, Rabeprazole) — Sometimes
- Raloxifene (Evista) — Rarely
- Raltegravir (Isentress) — Rarely
- Ramelteon (Rozerem) — Rarely
- Ramipril (Altace) — Can go either way
- Ranitidine (Zantac) — Rarely
- Rasagiline — Sometimes
- Ravulizumab (Ultomiris) — Rarely
- Regorafenib — Sometimes
- Relugolix (Orgovyx) — Rarely
- Remdesivir (Veklury) — Rarely
- Retifanlimab (Zynyz) — Sometimes
- Revefenacin — Sometimes
- Ribavirin (Copegus) — Rarely
- Rifampin (Rifadin) — Rarely
- Rilpivirine (Edurant) — Rarely
- Riluzole (Rilutek) — Sometimes
- Rimantadine — Sometimes
- Rimonabant (Acomplia) — Rarely
- Ripretinib (Qinlock) — Sometimes
- Risankizumab (Skyrizi) — Sometimes
- Risdiplam (Evrysdi) — Rarely
- Risperidone (Risperdal) — Can go either way
- Ritlecitinib (Litfulo) — Rarely
- Ritonavir (Norvir) — Rarely
- Rituximab (Rituxan) — Sometimes
- Rivaroxaban (Xarelto) — Rarely
- Rizatriptan — Sometimes
- Rolapitant — Sometimes
- Romiplostim — Sometimes
- Romosozumab (Evenity) — Rarely
- Ropinirole (Requip) — Can go either way
- Ropivacaine (Naropin) — Rarely
- Rosiglitazone (Avandia) — Rarely
- Rosuvastatin (Crestor) — Rarely
- Rotigotine (Neupro) — Sometimes
- Roxadustat (Evrenzo) — Rarely
- Rozanolixizumab (Rystiggo) — Rarely
- Rufinamide (Banzel) — Sometimes
- Ruxolitinib (Jakafi) — Rarely
S
- Sacituzumab govitecan (Trodelvy) — Sometimes
- Sacubitril/Valsartan (Entresto) — Rarely
- Safinamide (Xadago) — Sometimes
- Salbutamol (Ventolin) — Sometimes
- SAM-e — Sometimes
- Samidorphan — Sometimes
- Sarecycline (Seysara) — Rarely
- Sargramostim (Leukine) — Rarely
- Satralizumab (Enspryng) — Sometimes
- Saxagliptin (Onglyza) — Rarely
- Scopolamine (Transderm Scop) — Can go either way
- Selegiline (Eldepryl) — Sometimes
- Selexipag (Uptravi) — Rarely
- Selinexor (Xpovio) — Rarely
- Selpercatinib (Retevmo) — Rarely
- Selumetinib — Sometimes
- Semaglutide (Ozempic, Wegovy, Rybelsus) — Sometimes
- Seribantumab (MM-121) — Rarely
- Sertraline (Zoloft) — Sometimes
- Setmelanotide — Sometimes
- Sevoflurane (Ultane) — Sometimes
- Silodosin — Sometimes
- Siltuximab (Sylvant) — Sometimes
- Simeprevir (Olysio) — Rarely
- Simvastatin (Zocor) — Not a known cause
- Siponimod (Mayzent) — Sometimes
- Sirolimus (Rapamune) — Commonly causes dryness
- Sitagliptin (Januvia) — Rarely
- Smallpox Vaccine — Sometimes
- Sodium Oxybate (Xyrem) — Sometimes
- Solifenacin (Vesicare) — Commonly causes dryness
- Solriamfetol — Sometimes
- Sonidegib (Odomzo) — Rarely
- Sorafenib (Nexavar) — Commonly causes dryness
- Sotalol (Betapace) — Rarely
- Sotorasib (Lumakras) — Rarely
- Sparsentan (Filspari) — Rarely
- Spironolactone (Aldactone) — Sometimes
- St. John's Wort — Sometimes
- Stavudine (Zerit) — Rarely
- Strontium — Sometimes
- Sufentanil (Dsuvia) — Commonly causes dryness
- Sulfasalazine (Azulfidine) — Rarely
- Sumatriptan (Imitrex) — Sometimes
- Sunitinib (Sutent) — Commonly causes dryness
- Suvorexant — Sometimes
- Synthetic Conjugated Estrogens, B — Sometimes
T
- Tacrine (Cognex) — Rarely
- Tacrolimus (Prograf) — Sometimes
- Tadalafil (Cialis) — Rarely
- Tafasitamab (Monjuvi) — Rarely
- Tagraxofusp — Sometimes
- Talazoparib (Talzenna) — Sometimes
- Tamoxifen (Nolvadex) — Rarely
- Tamsulosin (Flomax) — Can go either way
- Tapentadol — Sometimes
- Tapinarof (Vtama) — Rarely
- Tazemetostat (Tazverik) — Rarely
- Teclistamab (Tecvayli) — Rarely
- Tegafur (Tegafur) — Sometimes
- Telmisartan (Telmisartan, telmisartan) — Sometimes
- Temazepam (Restoril) — Sometimes
- Temozolomide (Temodar) — Commonly causes dryness
- Temsirolimus (Torisel) — Commonly causes dryness
- Teniposide (Vumon) — Commonly causes dryness
- Tenofovir (Viread) — Rarely
- Tenofovir Disoproxil — Sometimes
- Teplizumab (Tzield) — Sometimes
- Tepotinib (Tepmetko) — Rarely
- Teprotumumab (Tepezza) — Rarely
- Terazosin (Hytrin) — Rarely
- Terbutaline (Terbutaline Sulfate) — Sometimes
- Teriflunomide (Aubagio) — Rarely
- Tetrabenazine (Xenazine) — Can go either way
- Tezacaftor/Ivacaftor (Symdeko) — Rarely
- Tezepelumab (Tezspire) — Rarely
- Thalidomide (Thalomid) — Rarely
- Theophylline (Theo-24) — Sometimes
- Thermogenic / "Fat Burner" blends — Commonly causes dryness
- Thioridazine (Mellaril) — Commonly causes dryness
- Thiothixene — Sometimes
- Thymol (Listerine and similar antiseptic rinses) — Irritates directly
- Tiagabine (Gabitril) — Sometimes
- Tildrakizumab (Ilumya) — Sometimes
- Tiotropium (Spiriva) — Can go either way
- Tiotropium/Olodaterol (Stiolto Respimat) — Sometimes
- Tirabrutinib (Velexbru) — Sometimes
- Tirbanibulin (Klisyri) — Rarely
- Tirzepatide (Mounjaro) — Sometimes
- Tisagenlecleucel (Kymriah) — Sometimes
- Tivozanib (Fotivda) — Commonly causes dryness
- Tixagevimab/Cilgavimab (Evusheld) — Sometimes
- Tizanidine (Zanaflex) — Commonly causes dryness
- Tocilizumab (Actemra) — Sometimes
- Tofacitinib (Xeljanz) — Sometimes
- Tolcapone (Tasmar) — Sometimes
- Tolterodine (Detrol) — Commonly causes dryness
- Tolvaptan (Samsca) — Rarely
- Topiramate (Topamax) — Commonly causes dryness
- Topotecan (Hycamtin) — Commonly causes dryness
- Torsemide (Demadex) — Commonly causes dryness
- Tovorafenib (Ojemda) — Rarely
- Trabectedin (Yondelis) — Sometimes
- Tralokinumab (Adbry) — Sometimes
- Tramadol (Ultram) — Sometimes
- Trametinib (Mekinist) — Rarely
- Trandolapril (Trandolapril) — Sometimes
- Tranylcypromine (Parnate) — Sometimes
- Trastuzumab — Sometimes
- Trastuzumab deruxtecan (Enhertu) — Sometimes
- Trastuzumab emtansine (Kadcyla) — Commonly causes dryness
- Trazodone (Desyrel) — Sometimes
- Treosulfan (Trecondi) — Sometimes
- Tretinoin — Sometimes
- Triamcinolone (inhaled) (Azmacort) — Sometimes
- Triamterene / hydrochlorothiazide (Dyazide, Maxzide) — Sometimes
- Triamterene/HCTZ (Dyazide) — Sometimes
- Trientine (Syprine) — Rarely
- Trifluoperazine (Stelazine) — Commonly causes dryness
- Trihexyphenidyl (Artane) — Commonly causes dryness
- Trilaciclib (Cosela) — Sometimes
- Trimeprazine — Sometimes
- Trimipramine (Surmontil) — Commonly causes dryness
- Triptorelin (Trelstar) — Rarely
- Tropicamide (Mydriacyl) — Commonly causes dryness
- Trospium (Sanctura) — Commonly causes dryness
- Tucatinib (Tukysa) — Sometimes
U
- Ublituximab (Briumvi) — Sometimes
- Ulipristal — Sometimes
- Umeclidinium (Incruse) — Commonly causes dryness
- Umeclidinium/Vilanterol (Anoro Ellipta) — Sometimes
- Upadacitinib (Rinvoq) — Sometimes
- Ustekinumab (Stelara) — Sometimes
- Uva Ursi — Sometimes
V
- Valacyclovir (Valtrex) — Rarely
- Valemetostat (Ezharmia) — Rarely
- Valerian — Sometimes
- Valganciclovir (Valcyte) — Rarely
- Valoctocogene roxaparvovec (Roctavian) — Rarely
- Valproate — Sometimes
- Valproic Acid (Depakote) — Sometimes
- Valrubicin (Valstar) — Sometimes
- Valsartan (Diovan) — Can go either way
- Vamorolone (Agamree) — Rarely
- Vandetanib (Caprelsa) — Sometimes
- Vardenafil (Vardenafil) — Sometimes
- Varenicline (Chantix) — Sometimes
- Velaglucerase alfa (VPRIV) — Rarely
- Velmanase alfa (Lamzede) — Rarely
- Vemurafenib (Zelboraf) — Rarely
- Venetoclax (Venclexta) — Rarely
- Venlafaxine (Effexor XR) — Commonly causes dryness
- Verapamil (Calan) — Rarely
- Vericiguat (Verquvo) — Rarely
- Vernakalant — Sometimes
- Vigabatrin — Sometimes
- Vilanterol/Fluticasone (Breo Ellipta) — Sometimes
- Vilazodone (Viibryd) — Sometimes
- Viloxazine (Qelbree) — Rarely
- Viltolarsen (Viltepso) — Rarely
- Vinblastine (Velban) — Commonly causes dryness
- Vincristine (Oncovin) — Commonly causes dryness
- Vindesine (Eldisine) — Sometimes
- Vipivotide Tetraxetan — Sometimes
- Vismodegib (Erivedge) — Rarely
- Vitamin B12 (Cyanocobalamin) — Not a known cause
- Vitamin C (high dose) — Rarely
- Vitamin D3 (Cholecalciferol) — Not a known cause
- Voclosporin (Lupkynis) — Rarely
- Volanesorsen — Sometimes
- Vonoprazan (Voquezna) — Rarely
- Voriconazole (Vfend) — Rarely
- Vorinostat (Zolinza) — Rarely
- Vortioxetine (Trintellix) — Rarely
- Vosoritide (Voxzogo) — Rarely
- Voxilaprevir (Vosevi) — Rarely
- Vutrisiran (Amvuttra) — Rarely
W
- Warfarin (Coumadin) — Not a known cause
Y
- Yohimbine — Commonly causes dryness
Z
- Zafirlukast (Accolate) — Rarely
- Zanamivir (Relenza) — Rarely
- Zanidatamab (Zymeworks (Investigational)) — Sometimes
- Zanubrutinib (Brukinsa) — Sometimes
- Zavegepant (Zavzpret) — Rarely
- Zidovudine (Retrovir) — Rarely
- Zileuton (Zyflo) — Rarely
- Zilucoplan (Zilbrysq) — Rarely
- Zinc lozenges (high use) — Rarely
- Ziprasidone (Geodon) — Can go either way
- Ziv-Aflibercept (Zaltrap) — Sometimes
- Zoledronic Acid (Reclast) — Rarely
- Zolmitriptan (Zomig) — Sometimes
- Zolpidem (Ambien) — Can go either way
- Zonisamide (Zonegran) — Can go either way
- Zopiclone (Imovane) — Can go either way
- Zuclopenthixol — Sometimes
- Zuranolone (Zurzuvae) — Sometimes